Загрузка...
Functional Nanostructured Carbon Honeycomb Monoliths for Hemoadsorption: Preliminary Studies on Biocompatibility, Protein-Bound Uremic Toxins and Inflammatory Cytokines Elimination
Автор(ы)
Jakpar Jandosov
Carol Angela Howell
Susan R. Sandeman
D. Chenchik
Sergey V. Mikhalovsky
Joaquín Silvestre‐Albero
Zulkhair Aimukhametovich Mansurov
Сейтхан Азат
Rosa Busquets
Nurzhamal Zhylybayeva
Михаил Цукерман
Alzhan Baimenov
Дата публикации
7 сентября 2026 г.
Тип
journal article
Издатель
Multidisciplinary Digital Publishing Institute
Том
27
Выпуск
17
Первая страница
7972
Последняя страница
7972
ISSN
1422-0067
Аннотация
Rice husk (RH) is a renewable siliceous lignocellulosic waste providing a unique, greener and less toxic alternative to conventional synthetic polymeric precursors in the production of carbon-based materials for biomedical applications. In this work we studied the porous structure of RH-lignin-based activated carbon produced in the form of honeycomb carbon monoliths and assessed their potential as hemoadsorbents for blood purification in the treatment of patients with serious medical conditions, such as kidney failure and sepsis. To determine their clinical suitability for such an application, the hemocompatibility and cytotoxicity of the monoliths were investigated using the standard ISO guidelines. The monoliths did not cause any changes in the cell viability or cell lysis. High micro/mesoporosity and surface chemistry of the initial monolith-C, N- and P-doped nanostructured carbon honeycomb monoliths were established by low-temperature nitrogen adsorption (LTNA) studies, mercury porosimetry data (MIP), SEM/EDS analysis and FT-IR spectroscopy. The micro-mesoporous, activated carbon-based filtration/adsorbent prototype devices, in the form of three-dimensional (3D) carbon matrix, functionalized with ion-exchange amino- and phosphate groups and encased in polyolefin heat shrink cable sleeve, have been developed with the capacity to remove protein-bound uremic toxins (PBUTs), such us PCS and IS, as well as inflammatory cytokines (IL-6 and IL-8) from human plasma in a flowing model system. The ammoxidized monolith-N, derived from the monolith-C, had the highest removal efficiency (40.05% for PCS, and 28.4% for IL-6). By contrast, phosphorylated monolith-P demonstrated the highest removal efficiency (54.62% for IS, and 54.4% for IL-8), whilst the monolith-C has the lowest removal efficiency for these adsorbates. These results do not correlate with the LTNA and MIP study results, suggesting that the interaction of surface chemical functional groups with the solutes play key roles in the adsorption mechanism. The ion-exchange mechanism of PBUTs and inflammatory cytokine chemisorption by the monoliths, modified with surface N- and P-containing functional groups, has been proposed.
Области науки (FoS)
Файл(ы)![Изображение-миниатюра]()
Загрузка...
Название
W7211877476.pdf
Описание
Полный текст в открытом доступе, лицензия cc-by; источник: https://cris.brighton.ac.uk/ws/files/69172264/ijms-27-07972-v3.pdf
Размер
4,62 MB
Формат
Adobe PDF
Контрольная сумма
(MD5):1a2c98204d9e555994216164fc6441e3