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Iodine-Based Coordination Compounds: A Strategy Toward Antibiotic Potentiation
Автор(ы)
Daniil Shepilov
Dana A. Askarova
Anar Seisembekova
Ardak B. Jumagaziyeva
Tamara Bukeyeva
Gulnara Yuldasheva
Nurdaulet Temir
Lyudmila N. Ivanova
Natalya V. Zubenko
Sabina T. Kenesheva
Дата публикации
12 мая 2026 г.
Тип
journal article
Издатель
Multidisciplinary Digital Publishing Institute
Том
27
Выпуск
10
Первая страница
4292
Последняя страница
4292
ISSN
1422-0067
Аннотация
Due to the increasing threat of antibiotic resistance and the emergence of new pathogenic strains, the development of effective combined therapeutic agents represents a crucial direction in the fight against infections. Within this study, several compounds were synthesized in which iodine is present in a coordination complex with antibiotics—sodium sulfadimidine and gentamicin sulfate. The physicochemical parameters of these compounds were investigated using capillary electrophoresis and UV spectroscopy, along with their cytotoxicity, antimicrobial, and antiviral activities. As a result of this work, two stable compounds, KC-246 and KC-248, were synthesized, demonstrating virus-inhibitory activity against herpes simplex virus and influenza A under extremely low cytotoxicity levels of 0.018–0.106 mg/mL. Additionally, they exhibited antimicrobial activity against representatives of the families Staphylococcaceae, Pseudomonadaceae, Enterobacteriaceae, Enterococcaceae, and yeast-like fungi. The minimum bactericidal concentrations (MBCs) ranged from 0.794 µg/mL to 0.198 µg/mL (KC-246) and from 2.093 µg/mL to 0.523 µg/mL (KC-248).
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