Қазақ ұлттық қыздар педагогикалық университеті / Казахский национальный женский педагогический университет

Постоянный URI для этого сообществаhttps://cris.qyzpu.kz/handle/123456789/1

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Автор: search.filters.author.Олександр Валерійович ОларЯзык: Английский

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    Layer-by-layer phase scanning of polycrystalline blood facies laser induced images for determination thyroid gland cancer and tissues injury necrosis
    (2024-12-16)
    Olexander G. Ushenko
    ;
    Oleksandr Vyacheslavovich Bilookyi
    ;
    Yuriyr Ushenko
    ;
    Olexander V. Dubolazov
    ;
    Irina V. Soltys
    The methods of layer-by-layer interference phase scanning with digital holographic reproduction of azimuth and ellipticity polarization maps for differential diagnosis of benign (nodular goiter - NG) and malignant (papillary thyroid - PT) thyroid tumours are presented. All studies in representative groups of histological sections M and AC were conducted using a circular laser beam. This ensured the azimuthal invariance and repeatability of measurements of polarization maps NG and PT. Integrated, and layer-by-layer polarization maps of NG and PT were received. Values of statistical moments of 1st - 4th order, which characterize NG and PT samples coordinate distributions of azimuth and ellipticity polarization have been determined and systematized. A set of statistical parameters - diagnostic markers most sensitive to changes in the polycrystalline structure NG and PT has been determined. The results of information analysis - determination of accuracy of vector-parametric and polarization-interference methods of differentiation of benign and malignant thyroid tumours are presented.
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    3D polarimetry of laser induced speckle fields for phase detection thyroid gland polycrystalline structure and traumatic necrosis of human internal organs
    (2024-12-16)
    Olexander G. Ushenko
    ;
    Oleksandr Vyacheslavovich Bilookyi
    ;
    Yuriy Ushenko
    ;
    Olexander V. Dubolazov
    ;
    Irina V. Soltys
    A short theory of the processes of formation of the laser speckle fields polarization structure of biological tissues with optically anisotropic architectonics is presented. A method of polarization interference mapping of speckle fields with layerby-layer phase scanning of holographically reconstructed distributions of complex amplitudes of biological preparations of various morphological structures and physiological states has been proposed and experimentally tested - biopsies of the thyroid gland and blood films of rats with different severity of sepsis. Layer-by-layer maps of polarization ellipticity of native histological sections of thyroid biopsies from donors and sick patients were studied. As part of the statistical analysis of phase coordinate distributions of polarization ellipticity, objective markers for the differential diagnosis of thyroid pathology were found - nodular goiter, autoimmune thyroiditis and papillary cancer. Very good (~90%) and excellent (≥90%) accuracy of differential diagnosis was achieved. Statistical markers for temporal monitoring of septic changes in polarization azimuth maps of polycrystalline blood films of rats were found. An example of further research using laser-induced autofluorescence polarimetry methods is presented.