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3D polarimetry of laser induced speckle fields for phase detection thyroid gland polycrystalline structure and traumatic necrosis of human internal organs
Автор(ы)
Olexander G. Ushenko
Oleksandr Vyacheslavovich Bilookyi
Yuriy Ushenko
Olexander V. Dubolazov
Irina V. Soltys
Олександр Валерійович Олар
Ivan Mikirin
Valeriy Skliarchuk
Olexander Salega
Oleksandr V. Karas
Gulbarshin Rakhimbayeva
Yuriy Rogovyi
Natalia Mykolayivna Kozan
Jun Bao Zheng
Zbigniew Omiotek
Дата публикации
16 декабря 2024 г.
Тип
conference paper
Журнал
Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments (WILGA)
Первая страница
7
Последняя страница
7
Аннотация
A short theory of the processes of formation of the laser speckle fields polarization structure of biological tissues with optically anisotropic architectonics is presented. A method of polarization interference mapping of speckle fields with layerby-layer phase scanning of holographically reconstructed distributions of complex amplitudes of biological preparations of various morphological structures and physiological states has been proposed and experimentally tested - biopsies of the thyroid gland and blood films of rats with different severity of sepsis. Layer-by-layer maps of polarization ellipticity of native histological sections of thyroid biopsies from donors and sick patients were studied. As part of the statistical analysis of phase coordinate distributions of polarization ellipticity, objective markers for the differential diagnosis of thyroid pathology were found - nodular goiter, autoimmune thyroiditis and papillary cancer. Very good (~90%) and excellent (≥90%) accuracy of differential diagnosis was achieved. Statistical markers for temporal monitoring of septic changes in polarization azimuth maps of polycrystalline blood films of rats were found. An example of further research using laser-induced autofluorescence polarimetry methods is presented.
Области науки (FoS)