Farmaciâ Kazahstana

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INFLUENCE OF SOIL COMPOSITION ON THE MORPHO-ANATOMICAL STRUCTURE OF THE ALOE VERA PLANT
(2025-01-23)
Elmira Imanova
;
A.B. Myrzabay
;
ZH.S. Tileubayeva
;
М.О. Айтжанова
;
А С Кожамжарова
Aloe is a plant that resembles a cactus and flourishes in hot, dry areas. It is grown in subtropical climates all throughout the world, including the border regions of New Mexico, Texas, California, and Arizona in the south. In medical practice, medicinal raw materials from plants are currently used as biogenic stimulants. Aloe vera contains more than 200 biologically active natural ingredients, including polysaccharides, vitamins, enzymes, amino acids, anthraquinones, saponins, organic acids, phytoncides, esters, phenols, resins, minerals and other elements that promote the absorption of nutrients, improve the functioning of the digestive system, strengthen the immune system, and also cleanse the body of toxins. It contains 20 amino acids, including essential ones for humans. Aloe gel is a storehouse of antioxidant vitamins A, C, E and B vitamins. Eight extremely important enzymes for humans were also found in this plant. The mineral complex in aloe is represented by calcium, copper, selenium, chromium, manganese, magnesium, potassium, sodium and zinc. This article presents a comparative analysis of the morpho-anatomical features of aloe vera from aloe arborescens, and also conducts a study of the anatomical structure of the Aloe vera L. plant in 4 variants grown in soil, collected from various mixtures.
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DEVELOPMENT, PHARMACEUTICAL EVALUATION, AND ASSESSMENT OF THE BACTERICIDAL ACTIVITY OF THE KC-250 TABLET FORMULATION AGAINST CLINICALLY SIGNIFICANT MICROORGANISMS
(2026-08-21)
Daniil Shepilov
;
Zhassur Taganov
;
Ardak B. Jumagaziyeva
;
Sabina T. Kenesheva
;
Saltanat Jumabayeva
Introduction: Conversion of iodine-containing complexes into solid dosage forms requires adequate tablet strength while preserving disintegration, release, and antimicrobial activity. This study aimed to develop a directly compressed KC-250 tablet formulation, evaluate its pharmaceutical quality, and determine its bactericidal activity against clinically significant bacteria. Methods: Tablets containing 60 mg of KC-250 at a target mass of 500 mg were prepared using MicroceLac® 100, povidone K30, and magnesium stearate. Compression forces of 3.24 and 6.96 kN were compared by friability and disintegration testing. The selected formulation was evaluated for pharmacopoeial quality attributes. Bactericidal activity against eight reference, resistant, and clinical bacterial strains was determined in triplicate by broth serial dilution followed by agar subculture. Results: Increasing compression force from 3.24 to 6.96 kN reduced friability from 0.81% to 0.21%, while disintegration increased from 1.62 to 4.62 min. Tablets produced at 6.96 kN had friability of 0.20%, a disintegration time of 4 min 54 s, a KC-250 content of 63.05 mg/tablet, and dissolution of 102.95% within 45 min. All evaluated attributes complied with the predefined acceptance criteria. Minimum bactericidal concentrations were 60 mg/mL for the tested Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa strains and 30 mg/mL for Enterococcus faecalis and Enterococcus faecium. Discussion: Compression at 6.96 kN provided the most appropriate balance between mechanical resistance and rapid disintegration without restricting KC-250 release. The retained bactericidal activity indicates that tablet formulation did not eliminate the antimicrobial function of KC-250 and supports further development of the selected MicroceLac® 100– povidone K30 matrix.

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