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Novel 7-Aryliden-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl- 3-aryl-2H-pyrazolo[4,3-c]pyridine Hydrochloride: Synthesis and Structure
Автор(ы)
V. К. Yu
Iskakova Tynyshtyk Kadyrovna
Kayrat M. Beketov
Aigul Malmakova
Kaldybay D. Praliyev
Т. М. Сейлханов
Kenneth Darrell Berlin
Дата публикации
31 марта 2022 г.
Тип
journal article
Том
24
Выпуск
1
Первая страница
43
Последняя страница
50
ISSN
1562-3920
Аннотация
A Claisen-Schmidt type reaction of 1-(2-ethoxyethyl)piperidin-4-one with different aromatic aldehydes led to corresponding dienones with a yield of 65‒71%. 7-Arylidene-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-aryl-2H-pyrazolo[4,3-c]pyridines were synthesized by heterocyclization of 3,5-diarylidene-piperidin-4-ones with phenylhydrazine hydrochloride in methanol at 70 °C over 4‒6 h. The X-ray crystal structure determination of 7-(p-methoxybenzyliden)-3,3a,4,5,6,7-(hexahydro-5-(2-ethoxyethyl)-2-phenyl-3-(p-methoxyphenyl)-2H-pyrazolo[4,3-c]pyridine hydrochloride (the deposition number is CCDC 862410) was completed. The piperidine and pyrazoline rings are close to a chair and envelope conformations, respectively.
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