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New Derivatives of Coumarin-3-carboxylic Acid Containing a Furopyridine Fragment: Synthesis and Some Properties
Автор(ы)
Alexey Vladimirovich Trifonov
Nurbol Orynbasaruly Appazov
R. Kh. Bagautdinova
Lyudmila K. Kibardina
Michail A. Pudovik
Anna Pavlovna Lyubina
Alexandra D. Voloshina
Almir Sabirovich Gazizov
A. E. Tolegen
Nurila A. Togyzbayeva
Marat I. Syzdykbayev
Rakhymzhan A. Turmanov
Elena Chugunova
Alexander Romanovich Burilov
Дата публикации
1 августа 2025 г.
Тип
journal article
Издатель
Pleiades Publishing
Том
95
Выпуск
8
Первая страница
2192
Последняя страница
2199
ISSN
1070-3632
Аннотация
Abstract As a result of this study, the first representative of coumarin-3-carboxylic acid containing a furopyridine fragment was obtained. It was demonstrated that this coumarin-3-carboxylic acid readily forms salts with various organic amines, diamines, as well as with alkali metal cations (Na, K) and ammonia. Testing of all obtained compounds against tumor cell lines M-HeLa and HuTu 80 revealed that a number of salt structures (specifically those based on 2-aminopyridine, 2,6-diaminopyridine, or sodium) exhibit cytotoxicity comparable to the reference drug, 5-fluorouracil.
Области науки (FoS)