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Russian Journal of Genetics

ISSN
1022-7954
1608-3369
Издатель
Pleiades Publishing
Ключевые слова

Genetic diversity and...

Chromosomal and Genet...

Genetic Mapping and D...

Forensic and Genetic ...

Genetic Associations ...

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    Тип записи:Публикация,
    Comparative Study of the DNA-Damaging Activity of Epichlorohydrin Using Escherichia coli Biosensors and the Comet Assay Method in Mice
    (Pleiades Publishing, 2021-09-01)
    К. Г. Орджоникидзе
    ;
    Е. В. Игонина
    ;
    Б. С. Жошибекова
    ;
    Serikbai K. Abilev
    Abstract A comparative study of the genotoxic effects of methylmethanesulfonate (MMS) and epichlorohydrin (ECH) was performed using bacterial E. coli biosensors and the comet assay method in mice. ECH was shown to induce weaker SOS response and expression of the alkA gene in bacterial cells compared to MMS. In vivo experiments on mice using the comet assay method showed DNA-damaging activity of ECH in cells of the liver, kidneys, and lungs after 3 h of exposure, same as of MMS. The levels of DNA damage caused by ECH in these organs after exposure for 3 h were lower than for MMS. The genotoxic effect of ECH after 18 h of exposure was statistically significant only in a dose of 20 mg/kg in kidney cells.
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