Research Journal of Pharmacy and Technology

Показано: 1 - 2 из 2

Некоторые метрики заблокированы вашими
настройками согласия
Isolation and Biotesting of Tannins from Eichhornia crassipes plants: Pom analyses and Antifungal/antiviral Pharmacophore sites Identification
(2025-04-12)
Gulzira Izmukhanovna Yernazarova
;
Aliya Amangeldievna Ramazanova
;
Svetlana Kazbekovna Turasheva
;
D. Mukasheva
;
Madina Amangeldinova
Nutrients produce various secondary metabolites, including biologically active compounds such as antifungals. The composition of E. Crassipes aquatic plant contains biologically active substances. In this article, the composition of substances in E. Crassipes was identified using IR, 1H, and 13C-NMR methods. The identified substances were characterized for biological activity using the PASS online program. This was based on their molecular structure. As a result of the program, compounds showing activity against light, viruses, earwigs, and bacteria were developed. The program's scope included testing the substances' antimicrobial activity using agar diffusion assay in experiments. Substances were extracted from the aquatic plant via chromatography-mass spectrometry, and their activity against earwigs was examined. The study revealed efficacy against Candida albicans and Candida utilis earwigs.
Некоторые метрики заблокированы вашими
настройками согласия
Extraction, Purification and Characterisation of four new alkaloids from the water plant Pistia stratiotes: POM Analyses and Identification of Potential Pharmacophore Sites
(2023-07-24)
Gulzira Izmukhanovna Yernazarova
;
Aliya Amangeldievna Ramazanova
;
Svetlana Kazbekovna Turasheva
;
Faisal A. Almalki
;
Taïbi Ben Hadda
Currently, during the period of intensive development of scientific production, it is important to obtain phytopreparations from sources of raw materials of plant origin. The biological diversity of plants is amazing. The study of the composition of aquatic plants rich in active substances of biotechnological significance is currently an urgent problem. Biologically active substances are involved in various regenerative reactions and metabolic processes in the organism, being part of enzymes. Alkaloids are important nitrogenous compounds found in the plant and are widely used in medicine. The aim of the present study was to identify alkaloid compounds from the composition of the aquatic plant Pistia stratiotes, grown in a model experiment in laboratory conditions by highly effective liquid chromatography and determine the molecular structure by nuclear magnetic resonance. In addition, based on the molecular structure of alkaloid compounds found in the aquatic plant Pistia stratiotes, a study of the properties of pharmaceutical activity was conducted on the pharmaceutical site POM (Petra/Osiris/Molinspiration). According to the results of the study, 4 types of identified alkaloids were identified by the IR, 1H, 13C-NMR method. They: 1-Aza-10-methoxy-4-methyl-2-oxo-1,2-dihydroanthracene-9-O-b-D-glucopyranoside, 4,6-dimethoxy-8-prenyloxyfuroquinoline, 4,7-dimethoxy-6 - (3’ - methyl-3’ - methoxy-2 ' - oxy) butyl-oxifuroquinoline , 4,7-dimethoxy-6 - (3’ - methyl-2’ - oxy-3 ' - chlorine)butyloxifuroquinoline. As a result of the analysis of the identified POM alkaloids (Petra/Osiris/Molinspiration), predictions of antitumor activity were made. The presence of a (NHd+--- Od-) moiety indicates a potential antitumor pharmacophore site. The challenge is to verify our hypothesis experimentally and to confront virtual POM data and real anticancer screening.
Цитирования (OpenAlex) 12Цитирования (OpenCitations) 8

Research Journal of Pharmacy and Technology

Фильтры

Настройки

Сортировать по

результатов на странице