Russian Journal of General Chemistry

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Synthesis of New α-Aminophosphonates Based on Cyclohexylamine
(Pleiades Publishing, 2020-06-01)
Аndrey V. Smolobochkin
;
Almir Sabirovich Gazizov
;
K. A. Doszhanova
;
A. B. Kuandykova
;
Б. Ж. Джиембаев
Abstract A series of new α-aminophosphonates was synthesized based on the acid-catalyzed Kabachnik–Fields reaction involving diethyl phosphite, cyclohexylamine and substituted benzaldehyde. Structure of the reaction products was established by IR, NMR spectroscopy, and mass spectrometry methods.
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New Derivatives of Coumarin-3-carboxylic Acid Containing a Furopyridine Fragment: Synthesis and Some Properties
(Pleiades Publishing, 2025-08-01)
Alexey Vladimirovich Trifonov
;
Nurbol Orynbasaruly Appazov
;
R. Kh. Bagautdinova
;
Lyudmila K. Kibardina
;
Michail A. Pudovik
Abstract As a result of this study, the first representative of coumarin-3-carboxylic acid containing a furopyridine fragment was obtained. It was demonstrated that this coumarin-3-carboxylic acid readily forms salts with various organic amines, diamines, as well as with alkali metal cations (Na, K) and ammonia. Testing of all obtained compounds against tumor cell lines M-HeLa and HuTu 80 revealed that a number of salt structures (specifically those based on 2-aminopyridine, 2,6-diaminopyridine, or sodium) exhibit cytotoxicity comparable to the reference drug, 5-fluorouracil.
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