Қазақ ұлттық қыздар педагогикалық университеті / Казахский национальный женский педагогический университет

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Язык: АнглийскийТема: search.filters.subject.flavonoids

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    Тип записи:Публикация,
    DETERMINATION OF COMPONENT COMPOSITION OF CHICORIUM PLANT
    (2017-01-01)
    Г. Е. Азимбаева
    This article describes the composition of the Cichorium plant (flower, leaf, leaf). The pH value of Cichorium plant (flower, leaf, leaf) was determined at pH value of the mark «I-160 MI». Extracted water was 80% ethyl alcohol and 2 hours in water. The moisture content of the Cichorium plant by gravimetric method, acidity, ascorbic acid, pectinic substances by tectimetric method, the size of macro-micro elements in the AAnalyst 400 by atomic-emission semiconductor spectral analysis and spectrophotometer at atomic absorbing method Shimadzu on the «AA 7000», Cichorium plant The photocalorimetry method was determined by photocalorimeter KFK-2 and KFK-3, protein Kvelald, by the method of photocororimetry, anthocyanes, flavonoids, polyphenols, carotene and sugar. Kleachatka AE By Ermakov's modification, using weight method, the crude fat content was determined by the Weight Method by Soxle Apparatus. The elemental size of the Cichorium plant (flower, stalk, leaf) was determined. As a result, it has been shown that copper, zinc, manganese, iron, cobalt, cadmium, calcium, magnesium, potassium, sodium are present. Also, according to the study, Cichorium plant contains flavonoids, proteins, pectinic substances, antibodies, anthocyanins, phenolic acids, carotene, polyphenols, and gumers.
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    Тип записи:Публикация,
    METHODS OF DISTRIBUTION OF THE POLYPHENOL EXTRACTS FROM THE LEAVES OF A PLANT CARTHAMUS
    (2018-01-01)
    Zh. M. Yergalyieva
    ;
    Г. Е. Азимбаева
    From the Carthamus plant leaf are extracted polyphenol extracts, composition and construction have been proven by methods of IR, UV spectral analysis. Ether extract is 3%, 360 nm wavelength e = 4,070 Rutine, Ethyl Acetate Extract 3,2%, its wavelength 350 nm, e = 4,268 Quercetin compound, 90% ethyl alcohol 2,92%, 365 nm Wavelength , e = 4,359 in the zone of quercetin, and 70% in ethyl alcohol 3,64%, 331 nm wavelength, e=4,359 in the zone of euclidein and the final 50% of ethyl alcohol in the extract was 2,79%, 329 nm, e=4,614 according to the compound of the acid compound. References [1] The National Encyclopedia of Kazakhstan. Almaty: The Kazakh Encyclopedia, 2009. P. 315. (Kazakh). [2] Polymbetova F., Abiyev S., Sarsenbaev B. Travel to the world of useful vegetation Almaty: Science, 1999. P. 46-47. (Kazakh). [3] Zimin В.М. The Library of Pharmaceutical Journal, the Comprehensive Medicine and Science. Almaty, 1993. P. 153. (Russian). [4] Kenesarina N.А. Plant physiology and basics of biochemistry. Akmola: Agrarian University, 2005. P. 68. (Kazakh). [5] Lazurevsky G.V., Terentyeva I.V., Shamshurin Sh.Sh. Practical work on chemical constitution. M.: Search. The Higher School, 1966. P. 17. [6] Ayazbekova M.A., Yerzhanov B.K. Chemistry of esophagus products. Almaty: Search. ATU, 1999. P. 60-60. (Russian). [7] Lazurevsky G.V., Terentyeva I.V., Shamshurin Sh.Sh. Practical work on chemical constitution. M.: Search. The Higher School, 1966. P. 17. (Russian). [8] Balzarini J. The mannose – specific plant lectin from Cymbidium hydridum and Epipachis helleborine and the specific plant lectin Urticadioca / J. Balzarini., J. Neyts, M. Schols Hosoya // Antivral Res. 1992. Vol. 18. P. 191-207. [9] Vegetable resources of the USSR: Spattering, their chemical composition, use: Semirestia Magnoliaceae - Limoniaceae / [Redkol: Sokolov PD [gl.] And L.: Nauka, 1984. P. 460. (Russian). [10] Korulkin D.U. Polyphenols of Sedum in Rastenia. Almaty, 1998. (Russian). [11] Policarpova T.A. Polyphenols production. Dissection of catechins from the green chay. 2004. P. 25-31. (Russian). [12] The National Encyclopedia of Kazakhstan. Almaty: The Kazakh Encyclopedia, 2004. P. 315. [13] Yergaliyeva Zh.M., Azimbayeva G.E., Research and distribution of extracts of phenolic compounds of the Carthamus plant // International scientific-practical conference on development of science and education in natural sciences. Almaty, 2016. P. 226-229. (Kazakh). [14] Tarasevich B.N. IR spectrum of basic classes of organic compounds, M.V.Lomonosov Moscow State University, chemistry faculty, Organic Chemistry Department. Moscow 2012. P. 25. (Russian). [15] Ergalieva Zh.M., Azimbayeva G.E. Methods of distribution of polyphenols from flower of Carthamus // 3rd international congress on social sciences, China to adriatic. Antalya, 2016. P. 20-24. (Kazakh).
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    Тип записи:Публикация,
    STUDY OF EXTRACTIVE SUBSTANCES OF HELIANTHUS TUBEROSUSE TUBERS
    (2018-01-01)
    B. M. Izteleu
    ;
    G. E. Azimbayeva
    ;
    А. А. Бакибаев
    ;
    Б. Ж. Джиембаев
    The article examines the extractive properties of tubers of helianthus tuberosuse from two regions of Almaty. The object of the study is the extracts obtained from the tuber Helianthus tuberosuse. The extraction of tubers from helianthus tuberosuse was carried out by various organic solvents. It was found that the extraction of extractive substances by a group of solvents with increasing polarity. The greatest yield of extractive substances comes from the extraction of benzene and ethyl acetate. The main extractive substances belong to coumarin compounds (umbellioron C9H6O3, isoscapolin C10H8O4, escuftine C9H6O4, herniarin C10H8O3, umbelliferone C9H6O3, coumarin C9H6O2) and flavonoid. References [1] Uzhanova V.M. The study of the influence of components of medicinal plant materials based on the obtained extracts // Chemia plant materials. 2001. N 3. P. 105-110. [2] Maysarov D.A., Nekhaenko G.N. Medicinal plants of South Kazakhstan in folk medicine. Almaty: Gasir, 2004. 205 p. [3] Naleev O.N., Karzhaubaev K.E. Jerusalem artichoke. Almaty, 2006. P. 7-12. [4] Leontiev V.N., Dubar D.A., Lugin V.G., Feskova, etc. Biological potential of Jerusalem artichoke as a raw material for the food and pharmaceutical industry // Chemistry, technology of organic substances and biotechnology. Works BSTU. 2014. N 4. P. 227-230. [5] Zelenkov V.N. Mediko-biological properties of Jerusalem artichoke concentrate (dried) and the experience of using dietary supplements based on it in medical practice // Actual problems of creating new drugs of plant origin. Proceedings of the 4th International Congress June 29 – 1 July 2000. Vel. Novgorod, 2000. P. 158-163. [6] Zelenkov V.N. Perspectives of using various dry forms of Jerusalem artichoke in phytodietics for cardiovascular diseases // Practical herbal medicine. 2002. N 2. P. 42-43. [7] Zykleva N.S. The study of polysaccharides of Jerusalem artichoke tubers and the creation on their basis of therapeutic and prophylactic agents: Aforet. dis. cand. pharmacist. sciences Pyatigorsk, 1998. P. 22-35. [8] Bezchasnik E.M., Dyachenko V.V., Kucher O.V. The process of extraction from medicinal plant materials. Pharmcom 1. 2003. P. 54-56. [9] Izteleu B.M., Azimbaeva G.E., Kudaibergenova G.N. Determination of biologically active substances from the aerial part of Helianthus tuberususe // Chemical Journal of Kazakhstan. 2013. N 2(42). P. 121-125. [10] Polezhaeva I.V., Polezhaeva N.I., Menuilo L.N., Pavlenko N.I., Levdansky V.A. Study of extractives Chamerium Angustifolium (L.) holum // Chemia rastytelny cheese. 2005. N 1. P. 25-29. [11] Ikramova M.B., Mirzorakhimov K.K., Rakhimova F.A. [and others]. UV Spectra of plant extracts // Scientific achievements of biology, chemistry, physics: collection of articles. st. on mater. 1 international scientific-practical. conf. Novosibirsk: SibAK, 2011. [12] Konoplev M.M. Pharmacognosy: Natural biologically active substances. Vitebsk, 2007. 272 p. [13] Burasheva G.Zh., Eskaliyeva B.Ya., Umbetova A.K. Tabiga kosylystar chemasyasyn negizdery. Almaty: Kazak University, 2013. P. 114-220.
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    Тип записи:Публикация,
    STUDY OF TANNING SUBSTANCES AND FLAVANOIDS IN THE LEAVES OF ASIAN AGRIMONY(AGRIMONIA ASIATICA JUZ.)
    (Al-Farabi Kazakh National University, 2024-01-01)
    Anar Nurgaiypovna Kaliyeva
    ;
    Nurgul Mamytova
    ;
    Г. Ж. Медеуова
    ;
    Damezhan Sadykova
    ;
    Zaida Rakhimova
    Asian agrimony (Agrimonia asiatica Juz) is a common wild plant including that growing within the territory of Kazakhstan, a very promising raw material for flavonoids and tanning substances release. These active substances have significant pharmacological potential. The article presents the results of work on determining the quantitative and qualitative composition of tannins and flavonoids in plant raw materials from the Asian agrimony (Agrimonia asiatica Juz). The presence of tanning substances and flavonoids in the extracts received from the above-ground part of Asian agrimony has been established by qualitative reactions. Various developers for paper chromatography have been used. The quantita-tive determination of flavonoids has been carried out in terms of the equivalent amount of quercetine, and the standard method of permanganatometric titration has been used to determine the quantitative content of tanning substances. Quantitative content of tanning substances in the leaves of Asian agri-mony (A. asiatica juz.) showed an 8,156 %, and a quantitative content of flavonoids showed 1,9 %. The purpose of the study is to determine the quantitative and qualitative composition of tannins and flavanoids in prepared herbal medicinal raw materials in order to identify the most promising objects for further research.
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    Тип записи:Публикация,
    Adaptation Features of Gentiana tianschanica Rupr. Populations to Environmental Factors in Kazakhstan
    (2024-01-01)
    Бекзат Тыныбеков
    ;
    Moldir Imanaliyeva
    ;
    Askhat Kuatbayev
    ;
    Gulmira Satybaldiyeva
    ;
    Elmira Boribay
    The study investigates the current state, floristic composition, and ecological characteristics of Gentiana tianschanica populations in the Ile-Alatau region, part of the Ile-Alatau National Park, Kazakhstan.Gentiana L., an ancient boreal genus, includes 31 species in Kazakhstan, such as the endemic Gentiana dschungarica.Known for medicinal uses, especially for gastrointestinal and urogenital disorders, interest in gentians has risen for ornamental and pharmacological applications.Nine natural populations of G. tianschanica were studied in diverse ecological and phytocoenotic conditions of the Ile-Alatau mountains.Soil analyses revealed significant differences in the physicochemical properties of the species' habitats.In the Kimasar Gorge, mountain-meadow chestnut soils with a light loamy texture were observed, while the Big Almaty Gorge featured dark chestnut soils rich in humus (7.36-18.78%)and nutrients such as nitrogen (120.4-140.0mg/kg), phosphorus (58-98 mg/kg), and potassium (470-1000 mg/kg).These findings emphasize the species 'adaptation to varying altitudinal and climatic zones.Phytochemical analysis showed G. tianschanica is rich in bioactive compounds, including phenolics, bitter glycosides, flavonoids, and alkaloids.Total phenol content reached 1567.17-9008.20mg of gallic acid/100 g, with the highest levels in leaves.Flavonoids (up to 1358.25 mg catechin/100 g) and vitamin C (up to 244.7 mg/100 g) were significant.Syringic acid (1685.8mg/100 g), quercetin (317.4 mg/100 g), and chlorogenic acid (237.5 mg/100 g) highlighted antioxidant and antiinflammatory potential.The antioxidant activity, particularly in leaves, reached 530.30 mg Trolox/100 g.Anthropogenic threats, including overgrazing and habitat disturbance, have led to declining populations, necessitating conservation strategies like habitat monitoring, protective regimes, and sustainable medicinal plant use.This study underscores the ecological and phytochemical significance of G. tianschanica, which is vital for biodiversity conservation and pharmaceutical development.
    Цитирования (OpenAlex) 2Цитирования (OpenCitations) 3
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    Phytochemical composition and antioxidant, antimicrobial, and cytotoxic activities of different solvent extracts of Ajania fastigiata (C. Winkl.) Poljakov
    (Instituto Internacional de Ecologia (Brazil), 2025-01-01)
    Assem Mamurova
    ;
    G. Kairanova
    ;
    G.A. Amеrtayeva
    ;
    Aigul Yedilova
    ;
    Asylkhan A. Rakhymzhan
    This study investigates the phytochemical composition and biological activities of six solvent extracts-hexane, ethyl acetate, and hydroethanolic fractions-from the roots and aerial parts of Ajania fastigiata (C. Winkl.) Poljakov (Asteraceae), collected in the mountain regions of southeastern Kazakhstan. Phytochemical analysis revealed that the aerial ethyl acetate extract contained the highest levels of bioactive metabolites, including phenolic compounds (34.22 ± 1.98 mg GAE/g), flavonoids (2.74%), organic acids (1.91%), and coumarins (0.54%). Antioxidant potential was evaluated using DPPH and ABTS radical-scavenging assays, with values of SC50 = 133.98 ± 12.91 µg/mL (DPPH) and 209.21 ± 3.70 mg Trolox/g (ABTS). The minimum inhibitory concentration (MIC), determined by the broth microdilution method, showed strong antimicrobial activity of the aerial ethyl acetate fraction, particularly against P.aeruginosa (MIC = 9 µg/mL) and E.faecalis (MIC = 39 µg/mL). Cytotoxicity was assessed by the MTT assay on NIH-3T3, K562, and Saos cell lines. The aerial ethyl acetate fraction exhibited selective cytotoxic effects, with IC50 values of 210 µg/mL for K562 and 360 µg/mL for Saos, while showing negligible activity toward normal fibroblasts (IC50 > 2500 µg/mL). These results confirm the pharmacological potential of A.fastigiata as a promising natural source of antioxidant, antimicrobial, and anticancer agents.
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    Comparative phytochemical and GC-MS analysis of leaves, stems, and roots of Euphorbia yaroslavii Poljakov.
    (Instituto Internacional de Ecologia (Brazil), 2026-01-01)
    Abibulla Ametov
    ;
    Marzhankul Dauletbayeva
    ;
    М.О. Айтжанова
    ;
    Zaida Rakhimova
    ;
    Sarsembayeva Aiman
    Euphorbia yaroslavii Poljakov. is a rare plant species endemic to Kazakhstan whose phytochemical composition has remained largely unexplored. This study presents the first organ-specific phytochemical and GC-MS characterization of the leaves, stems, and roots of this species. Quantitative analyses indicated pronounced metabolic differentiation among plant organs. Roots were characterized by high contents of total phenolics (58.2 ± 2.5 mg GAE/g DW), coumarins (2.48%), and mineral components (total ash 13.22%), while leaves exhibited the highest tannin content (2.35%). The maximum flavonoid content was observed in roots (0.27%), whereas stems contained the highest level of ascorbic acid (0.70 mg/g DW). GC-MS profiling tentatively identified 68 compounds in leaf extracts, 65 in stem extracts, and 39 in root extracts. Root extracts were dominated by fatty acids and triterpenoid-sterol constituents, including octadecanoic acid (18.9%), hexadecanoic acid (17.5%), β-amyrin (5.2%), and lanosterol (4.9%). Overall, the results indicate organ-specific metabolic specialization in Euphorbia yaroslavii Poljakov. and provide a reliable phytochemical baseline for future bioactivity-oriented and conservation-related studies.
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    Phytochemical Profiling and Toxicological Evaluation of Atraphaxis virgata and Atraphaxis pyrifolia Extracts Using GC–MS and LC–MS
    (Multidisciplinary Digital Publishing Institute, 2026-05-23)
    Meruyert D. Dauletova
    ;
    Almagul K. Umbetova
    ;
    Aisulu Zh. Kabdraisova
    ;
    Ryzvangul S. Ymynova
    ;
    G. Sh. Burasheva
    Atraphaxis virgata and Atraphaxis pyrifolia are xerophytic species of the Polygonaceae family that remain insufficiently characterized from pharmacognostic, phytochemical, and toxicological perspectives. This study provides an integrated evaluation of both species through anatomical authentication, sequential extraction of CO2-extracted residual biomass, GC–MS and LC–MS metabolite profiling, and acute oral toxicity assessment. Anatomical analysis revealed shared xeromorphic traits, including cuticular protection, dorsiventral mesophyll organization, structured vascular bundles, and calcium oxalate druses. It also identified species-specific differences in leaf thickness, mesophyll arrangement, vascular architecture, and druse morphology. GC–MS analysis showed distinct chemical profiles: A. virgata displayed a concentrated profile dominated by acetophenone- and benzofuran-related constituents, whereas A. pyrifolia showed a broader spectrum of carbohydrate-derived, phenolic-related, and oxygenated constituents. LC–MS analysis supported the tentative annotation of diverse polyphenolic classes, including flavonoids, phenolic acids, coumarins, and phenylpropanoid derivatives. Acute oral toxicity testing showed no mortality at doses up to 2000 mg/kg, supporting a low acute oral toxicity classification under the tested conditions. However, histological examination revealed mild to moderate dose-dependent alterations in liver and kidney tissues at higher doses. The novelty of this work lies in linking diagnostic anatomical traits, species-specific metabolite patterns, residual biomass valorization, and preliminary safety evidence within a single comparative framework. These findings provide a basis for pharmacognostic authentication, phytochemical standardization, and future bioactivity-guided evaluation of Atraphaxis species.