Қазақ ұлттық қыздар педагогикалық университеті / Казахский национальный женский педагогический университет

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STUDY OF EXTRACTIVE SUBSTANCES OF HELIANTHUS TUBEROSUSE TUBERS
(2018-01-01)
B. M. Izteleu
;
G. E. Azimbayeva
;
А. А. Бакибаев
;
Б. Ж. Джиембаев
The article examines the extractive properties of tubers of helianthus tuberosuse from two regions of Almaty. The object of the study is the extracts obtained from the tuber Helianthus tuberosuse. The extraction of tubers from helianthus tuberosuse was carried out by various organic solvents. It was found that the extraction of extractive substances by a group of solvents with increasing polarity. The greatest yield of extractive substances comes from the extraction of benzene and ethyl acetate. The main extractive substances belong to coumarin compounds (umbellioron C9H6O3, isoscapolin C10H8O4, escuftine C9H6O4, herniarin C10H8O3, umbelliferone C9H6O3, coumarin C9H6O2) and flavonoid. References [1] Uzhanova V.M. The study of the influence of components of medicinal plant materials based on the obtained extracts // Chemia plant materials. 2001. N 3. P. 105-110. [2] Maysarov D.A., Nekhaenko G.N. Medicinal plants of South Kazakhstan in folk medicine. Almaty: Gasir, 2004. 205 p. [3] Naleev O.N., Karzhaubaev K.E. Jerusalem artichoke. Almaty, 2006. P. 7-12. [4] Leontiev V.N., Dubar D.A., Lugin V.G., Feskova, etc. Biological potential of Jerusalem artichoke as a raw material for the food and pharmaceutical industry // Chemistry, technology of organic substances and biotechnology. Works BSTU. 2014. N 4. P. 227-230. [5] Zelenkov V.N. Mediko-biological properties of Jerusalem artichoke concentrate (dried) and the experience of using dietary supplements based on it in medical practice // Actual problems of creating new drugs of plant origin. Proceedings of the 4th International Congress June 29 – 1 July 2000. Vel. Novgorod, 2000. P. 158-163. [6] Zelenkov V.N. Perspectives of using various dry forms of Jerusalem artichoke in phytodietics for cardiovascular diseases // Practical herbal medicine. 2002. N 2. P. 42-43. [7] Zykleva N.S. The study of polysaccharides of Jerusalem artichoke tubers and the creation on their basis of therapeutic and prophylactic agents: Aforet. dis. cand. pharmacist. sciences Pyatigorsk, 1998. P. 22-35. [8] Bezchasnik E.M., Dyachenko V.V., Kucher O.V. The process of extraction from medicinal plant materials. Pharmcom 1. 2003. P. 54-56. [9] Izteleu B.M., Azimbaeva G.E., Kudaibergenova G.N. Determination of biologically active substances from the aerial part of Helianthus tuberususe // Chemical Journal of Kazakhstan. 2013. N 2(42). P. 121-125. [10] Polezhaeva I.V., Polezhaeva N.I., Menuilo L.N., Pavlenko N.I., Levdansky V.A. Study of extractives Chamerium Angustifolium (L.) holum // Chemia rastytelny cheese. 2005. N 1. P. 25-29. [11] Ikramova M.B., Mirzorakhimov K.K., Rakhimova F.A. [and others]. UV Spectra of plant extracts // Scientific achievements of biology, chemistry, physics: collection of articles. st. on mater. 1 international scientific-practical. conf. Novosibirsk: SibAK, 2011. [12] Konoplev M.M. Pharmacognosy: Natural biologically active substances. Vitebsk, 2007. 272 p. [13] Burasheva G.Zh., Eskaliyeva B.Ya., Umbetova A.K. Tabiga kosylystar chemasyasyn negizdery. Almaty: Kazak University, 2013. P. 114-220.
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Study of the chemical composition of raw alcohol obtained from the tuber of dahlia
(2022-06-15)
A. K. Kamysbayeva
;
G. E. Azimbayeva
;
Nurbala Myrzakhmetova
;
Z.M. Argynbayeva
;
Г. Ж. Медеуова
The raw material for alcohol production is a variety of plant materials, which contain sufficient amounts of digestible sugars or other carbohydrates that can be saccharified. Dahlias are tuberous plants of the Asteraceae family with a quick and powerful growth and a long vegetation period. The study of the chemical composition of dahlia tubers is of undoubted interest in terms of practical health care. Dahlia tubers are the main raw material for obtaining inulin, which has a wide range of pharmacological action. The vegetative (aboveground) part of dahlia has been an object of research. The purpose of this study has been to study the chemical composition of raw alcohol, obtained from the dahlia tubers. For this purpose, the chemical composition of the tuber of dahlia plants belonging to the Compositae family has been studied. It has been found that the tubers of dahlia contain a large amount of biologically active substances: protein, coumarin, polyphenol, pectin and inulin. Dry alcoholic yeast (TC BY 100104781.010-2005 dried alcoholic yeast Saccharomyces cerevisiae produced in Belarus) has been used as yeast. The fermentation process has taken place at the room temperature for 2-3 weeks. After 2 weeks it has been filtered, the quantity of wort has been measured and distilled. The chemical composition of the raw alcohol, obtained from dahlia tubers has been identified on an Agilent 7890A/5975C chromato-mass spectrometer.
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Phytochemical composition and antioxidant, antimicrobial, and cytotoxic activities of different solvent extracts of Ajania fastigiata (C. Winkl.) Poljakov
(Instituto Internacional de Ecologia (Brazil), 2025-01-01)
Assem Mamurova
;
G. Kairanova
;
G.A. Amеrtayeva
;
Aigul Yedilova
;
Asylkhan A. Rakhymzhan
This study investigates the phytochemical composition and biological activities of six solvent extracts-hexane, ethyl acetate, and hydroethanolic fractions-from the roots and aerial parts of Ajania fastigiata (C. Winkl.) Poljakov (Asteraceae), collected in the mountain regions of southeastern Kazakhstan. Phytochemical analysis revealed that the aerial ethyl acetate extract contained the highest levels of bioactive metabolites, including phenolic compounds (34.22 ± 1.98 mg GAE/g), flavonoids (2.74%), organic acids (1.91%), and coumarins (0.54%). Antioxidant potential was evaluated using DPPH and ABTS radical-scavenging assays, with values of SC50 = 133.98 ± 12.91 µg/mL (DPPH) and 209.21 ± 3.70 mg Trolox/g (ABTS). The minimum inhibitory concentration (MIC), determined by the broth microdilution method, showed strong antimicrobial activity of the aerial ethyl acetate fraction, particularly against P.aeruginosa (MIC = 9 µg/mL) and E.faecalis (MIC = 39 µg/mL). Cytotoxicity was assessed by the MTT assay on NIH-3T3, K562, and Saos cell lines. The aerial ethyl acetate fraction exhibited selective cytotoxic effects, with IC50 values of 210 µg/mL for K562 and 360 µg/mL for Saos, while showing negligible activity toward normal fibroblasts (IC50 > 2500 µg/mL). These results confirm the pharmacological potential of A.fastigiata as a promising natural source of antioxidant, antimicrobial, and anticancer agents.
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New Derivatives of Coumarin-3-carboxylic Acid Containing a Furopyridine Fragment: Synthesis and Some Properties
(Pleiades Publishing, 2025-08-01)
Alexey Vladimirovich Trifonov
;
Nurbol Orynbasaruly Appazov
;
R. Kh. Bagautdinova
;
Lyudmila K. Kibardina
;
Michail A. Pudovik
Abstract As a result of this study, the first representative of coumarin-3-carboxylic acid containing a furopyridine fragment was obtained. It was demonstrated that this coumarin-3-carboxylic acid readily forms salts with various organic amines, diamines, as well as with alkali metal cations (Na, K) and ammonia. Testing of all obtained compounds against tumor cell lines M-HeLa and HuTu 80 revealed that a number of salt structures (specifically those based on 2-aminopyridine, 2,6-diaminopyridine, or sodium) exhibit cytotoxicity comparable to the reference drug, 5-fluorouracil.
Цитирования (OpenAlex) 1Цитирования (OpenCitations) 1
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Comparative phytochemical and GC-MS analysis of leaves, stems, and roots of Euphorbia yaroslavii Poljakov.
(Instituto Internacional de Ecologia (Brazil), 2026-01-01)
Abibulla Ametov
;
Marzhankul Dauletbayeva
;
М.О. Айтжанова
;
Zaida Rakhimova
;
Sarsembayeva Aiman
Euphorbia yaroslavii Poljakov. is a rare plant species endemic to Kazakhstan whose phytochemical composition has remained largely unexplored. This study presents the first organ-specific phytochemical and GC-MS characterization of the leaves, stems, and roots of this species. Quantitative analyses indicated pronounced metabolic differentiation among plant organs. Roots were characterized by high contents of total phenolics (58.2 ± 2.5 mg GAE/g DW), coumarins (2.48%), and mineral components (total ash 13.22%), while leaves exhibited the highest tannin content (2.35%). The maximum flavonoid content was observed in roots (0.27%), whereas stems contained the highest level of ascorbic acid (0.70 mg/g DW). GC-MS profiling tentatively identified 68 compounds in leaf extracts, 65 in stem extracts, and 39 in root extracts. Root extracts were dominated by fatty acids and triterpenoid-sterol constituents, including octadecanoic acid (18.9%), hexadecanoic acid (17.5%), β-amyrin (5.2%), and lanosterol (4.9%). Overall, the results indicate organ-specific metabolic specialization in Euphorbia yaroslavii Poljakov. and provide a reliable phytochemical baseline for future bioactivity-oriented and conservation-related studies.
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Phytochemical Profiling and Toxicological Evaluation of Atraphaxis virgata and Atraphaxis pyrifolia Extracts Using GC–MS and LC–MS
(Multidisciplinary Digital Publishing Institute, 2026-05-23)
Meruyert D. Dauletova
;
Almagul K. Umbetova
;
Aisulu Zh. Kabdraisova
;
Ryzvangul S. Ymynova
;
G. Sh. Burasheva
Atraphaxis virgata and Atraphaxis pyrifolia are xerophytic species of the Polygonaceae family that remain insufficiently characterized from pharmacognostic, phytochemical, and toxicological perspectives. This study provides an integrated evaluation of both species through anatomical authentication, sequential extraction of CO2-extracted residual biomass, GC–MS and LC–MS metabolite profiling, and acute oral toxicity assessment. Anatomical analysis revealed shared xeromorphic traits, including cuticular protection, dorsiventral mesophyll organization, structured vascular bundles, and calcium oxalate druses. It also identified species-specific differences in leaf thickness, mesophyll arrangement, vascular architecture, and druse morphology. GC–MS analysis showed distinct chemical profiles: A. virgata displayed a concentrated profile dominated by acetophenone- and benzofuran-related constituents, whereas A. pyrifolia showed a broader spectrum of carbohydrate-derived, phenolic-related, and oxygenated constituents. LC–MS analysis supported the tentative annotation of diverse polyphenolic classes, including flavonoids, phenolic acids, coumarins, and phenylpropanoid derivatives. Acute oral toxicity testing showed no mortality at doses up to 2000 mg/kg, supporting a low acute oral toxicity classification under the tested conditions. However, histological examination revealed mild to moderate dose-dependent alterations in liver and kidney tissues at higher doses. The novelty of this work lies in linking diagnostic anatomical traits, species-specific metabolite patterns, residual biomass valorization, and preliminary safety evidence within a single comparative framework. These findings provide a basis for pharmacognostic authentication, phytochemical standardization, and future bioactivity-guided evaluation of Atraphaxis species.

Қазақ ұлттық қыздар педагогикалық университеті / Казахский национальный женский педагогический университет

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