Қазақ ұлттық қыздар педагогикалық университеті / Казахский национальный женский педагогический университет

Постоянный URI для этого сообществаhttps://cris.qyzpu.kz/handle/123456789/1

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Язык: АнглийскийТема: search.filters.subject.bioavailability

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    Providing bioavailability of plant antioxidants using encapsulation processes
    (American Institute of Physics, 2021-01-01)
    Rinat Il'gidarovich Fatkullin
    ;
    Ирина Юрьевна Потороко
    ;
    Irina Valer'evna Kalinina
    ;
    Zhanar Kenzheyeva
    ;
    Elzira Kyrbassova
    The purpose of this study was to study the possibility of using technologies for encapsulating flavonoids to ensure their bioavailability. The study evaluated the possibility of using two approaches to encapsulation: encapsulation in β-cyclodextrin and complex coacervation using gelatin and pectin. The effectiveness of the approaches was evaluated by the indicators of total antioxidant activity (DPPH method) and the calculation of the bioactivity index and bioavailability using the in vitro digestion model. The results of determining the total antioxidant activity showed that the encapsulation of taxifolin led to a slight decrease in the values of the indicator, by about 19.3 % when using encapsulation in β-cyclodextrin and 25.4% when using coacervation. The bioactivity index values for the encapsulated forms were 72.4 and 86.8 % when encapsulating in β-cyclodextrin and coacervation, respectively, versus 51.2 % for the original form of taxifolin. Encapsulation technologies made it possible to ensure the safety of taxifolin by 1.2 and 1.8 times in comparison with the control when using encapsulation in β-cyclodextrin and coacervation, respectively.
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    Antioxidant Activity and Bioavailability of Humic Substances of Low-Mineralized Sulphide Mud
    (2023-01-01)
    Ж. К. Каирбеков
    ;
    S.M. Suimbayeva
    ;
    Индира Мухаметкеримовна Джелдыбаева
    ;
    Manshuk Z. Esenalieva
    ;
    А.Ж. Каирбеков
    Humic substances (HS) are natural compounds, the formation of which occurs in natural environments as a result of chemical and biological decomposition.HS accounts for 60% to 80% of organic matter in soil and aquatic environment.Therefore, we obtained samples of HS isolated from low-mineralized sulphide mud deposits of Tuzkol Lake (Republic of Kazakhstan) were obtained.HS samples have been characterized by instrumental methods: EPR spectroscopy and amperometry.Analysis of the concentration of paramagnetic centers shows that the minimum number of free radicals contains molecules of fulvic acids, and the maximum number of free radicals contains molecules of humic acids (HA) of peloids.The antioxidant activity and bioavailability of humic preparations in the form of sodium humates depending on the concentration of HS have been investigated.The information obtained indicates that HS have antioxidant activity and bioavailability, the value of which increases when the concentration of the solution grows.Dialysis of silver humate has been carried out in the presence of dimethyl sulfoxide (DMSO) at concentrations of 0.1; 1.0; 5.0 and 10% w/w.For HA and silver humate, a 10% concentration of DMSO is optimal, which allows a maximum yield of peloid preparations and a 1.6-fold increase in permeability.Dialysis of silver humate is 1.2 times more intensive than dialysis of HA.It has been shown that the change in the total content of antioxidants in various fractions of humic substances increases in the series; fulvic -humic -gimatomelanic acids.
    Цитирования (OpenAlex) 1