Қазақ ұлттық қыздар педагогикалық университеті / Казахский национальный женский педагогический университет

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БИОЛОГ ЗЕРТТЕУШІНІҢ ІЗДЕНІМПАЗДЫЛЫҚ ІСКЕРЛІГІН ҚАЛЫПТАСТЫРУДЫҢ НЕГІЗІ
(Al-Farabi Kazakh National University, 2020-04-15)
Aidana Ramazanova
;
Gulbarshyn Yernazarova
;
Svetlana Kazbekovna Turasheva
;
B Kudaibergenova
Now in the countries of the world an actual problem becomes preparation of the qualified, talented, competitive experts who continuously develop in various branches of science and education, from year to year technologies are updated, introduced into the industrial branch. In this regard, changes and additions to the legislation of the country’s education system are made from year to year. There fore, an important role in providing in-depth knowledge of future specialists in our country is played by many effective methods of training in the educational process. The article offers methods of formation of research activity of students. The study of biology shows the division of students into groups in the formation of business activities of students and the implementation of jointly proposed project research sessions “Determination of biologically active substances of vegetative organs of plants.” Defining, forming, controlling, analytical levels of lessons of project research are described, efficiency of formation of research competence of future specialists-biologists as a result of research activity on this level is characterized. The result of joint activities is a group final product, which is often in the form of a report. The result of this work-high cognitive and educational motivation of students in the development of research and search activities-provides an increase in the creative efforts of the teacher. The results of a survey of 40 students based on the outcome of the use of research methods of training are presented in the article. The result of using the method is a high cognitive and learning motivation of students in the development of research and search activities, which provided the development of creative skills of both students and teachers. Key words: Research activity, group training, project, laboratory work, plants, biologically active substances.
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Extraction, Purification and Characterisation of four new alkaloids from the water plant Pistia stratiotes: POM Analyses and Identification of Potential Pharmacophore Sites
(2023-07-24)
Gulzira Izmukhanovna Yernazarova
;
Aliya Amangeldievna Ramazanova
;
Svetlana Kazbekovna Turasheva
;
Faisal A. Almalki
;
Taïbi Ben Hadda
Currently, during the period of intensive development of scientific production, it is important to obtain phytopreparations from sources of raw materials of plant origin. The biological diversity of plants is amazing. The study of the composition of aquatic plants rich in active substances of biotechnological significance is currently an urgent problem. Biologically active substances are involved in various regenerative reactions and metabolic processes in the organism, being part of enzymes. Alkaloids are important nitrogenous compounds found in the plant and are widely used in medicine. The aim of the present study was to identify alkaloid compounds from the composition of the aquatic plant Pistia stratiotes, grown in a model experiment in laboratory conditions by highly effective liquid chromatography and determine the molecular structure by nuclear magnetic resonance. In addition, based on the molecular structure of alkaloid compounds found in the aquatic plant Pistia stratiotes, a study of the properties of pharmaceutical activity was conducted on the pharmaceutical site POM (Petra/Osiris/Molinspiration). According to the results of the study, 4 types of identified alkaloids were identified by the IR, 1H, 13C-NMR method. They: 1-Aza-10-methoxy-4-methyl-2-oxo-1,2-dihydroanthracene-9-O-b-D-glucopyranoside, 4,6-dimethoxy-8-prenyloxyfuroquinoline, 4,7-dimethoxy-6 - (3’ - methyl-3’ - methoxy-2 ' - oxy) butyl-oxifuroquinoline , 4,7-dimethoxy-6 - (3’ - methyl-2’ - oxy-3 ' - chlorine)butyloxifuroquinoline. As a result of the analysis of the identified POM alkaloids (Petra/Osiris/Molinspiration), predictions of antitumor activity were made. The presence of a (NHd+--- Od-) moiety indicates a potential antitumor pharmacophore site. The challenge is to verify our hypothesis experimentally and to confront virtual POM data and real anticancer screening.
Цитирования (OpenAlex) 12Цитирования (OpenCitations) 8
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Isolation and Biotesting of Tannins from Eichhornia crassipes plants: Pom analyses and Antifungal/antiviral Pharmacophore sites Identification
(2025-04-12)
Gulzira Izmukhanovna Yernazarova
;
Aliya Amangeldievna Ramazanova
;
Svetlana Kazbekovna Turasheva
;
D. Mukasheva
;
Madina Amangeldinova
Nutrients produce various secondary metabolites, including biologically active compounds such as antifungals. The composition of E. Crassipes aquatic plant contains biologically active substances. In this article, the composition of substances in E. Crassipes was identified using IR, 1H, and 13C-NMR methods. The identified substances were characterized for biological activity using the PASS online program. This was based on their molecular structure. As a result of the program, compounds showing activity against light, viruses, earwigs, and bacteria were developed. The program's scope included testing the substances' antimicrobial activity using agar diffusion assay in experiments. Substances were extracted from the aquatic plant via chromatography-mass spectrometry, and their activity against earwigs was examined. The study revealed efficacy against Candida albicans and Candida utilis earwigs.
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Nutritive and Prebiotic Potentials of Chlorella and Scenedesmus Microalgae
(2026-01-01)
Gulzira Izmukhanovna Yernazarova
;
С. К. Кабдрахманова
;
Svetlana Kazbekovna Turasheva
;
А.А. Ramazanova
;
Khaiyrnisa Aisakulova
We investigated the prebiotic properties of Chlorella sp. and Scenedesmus sp.microalgae based on the analysis of their extracts.We used High-performance liquid chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR) for chemical characterisation of extract composition.Using HPLC at 272 nm, the flavonoid naringenin was identified in the extract at a concentration of 1.343
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Investigation of the Antimicrobial Activity of Biologically Active Substances Extracted from the Callus Cell Cultures of Rheum cordatum Losinsk and Rheum tataricum L. Plants (Family Polygonaceae) using Fourier infrared Spectroscopy to Analyze the Chemical Composition and Identify Active Compounds
(2026-03-16)
Madina Amangeldinova
;
Nataliya O. Kudrina
;
Gulzira Izmukhanovna Yernazarova
;
Svetlana Kazbekovna Turasheva
;
Metin Yildirim
The increasing demand for novel antimicrobial agents has led to interest in plant-derived bioactive substances (BAS). This study focuses on the establishment of callus cultures from Rheum cordatum Losinsk. and Rheum tataricum L. under in vitro conditions and the evaluation of the antimicrobial properties of BAS synthesized in these callus cells. Callus cultures were induced from leaf and stem explants using Murashige-Skoog nutrient medium supplemented with 2,4-D (0.1mg/L) and BAP (0.01mg/L). Callus formation frequency was recorded for both species, and green plant regeneration from R. cordatum calluses was observed. Antimicrobial activity was assessed by testing callus-derived extracts against various microorganisms, including gram-positive Staphylococcus aureus 6538 and Salmonella abony NTCC 6017, gram-negative Escherichia coli NTCC 8439 and Klebsiella pneumonia 700603, and the yeast-like fungus Candida albicans R50. Callus induction was successfully achieved in both species, with formation frequencies of 60±6% for R. cordatum and 72±8% for R. tataricum. Extracts from R. tataricum callus cultures exhibited antimicrobial activity against S. aureus, E. coli, and K. pneumoniae. R. cordatum callus extracts showed moderate effects on these microorganisms. The results highlight the significant potential of callus-derived rhubarb extracts in addressing bacterial and fungal pathogens. The study demonstrates the efficacy of Murashige-Skoog medium supplemented with 2,4-D and BAP in promoting callus induction and growth in rhubarb species. Extracts from rhubarb callus tissues represent significant potential in developing new antimicrobial agents effective against a wide range of pathogens, including bacterial and fungal infections. Future studies will focus on the regeneration of plants from callus cultures and the detailed pharmacological profiling of their BAS.

Қазақ ұлттық қыздар педагогикалық университеті / Казахский национальный женский педагогический университет

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