Жарияланымдар / Публикации

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  • Некоторые метрики заблокированы вашими 
    Тип записи:Публикация,
    BIOLOGICAL FEATURES OF MEDICINAL PLANT ELAEAGNUS RHAMNOIDES GROWING AT SOUTH-EAST OF KAZAKHSTAN
    (2020-12-20) ; ;
    Bekbossyn Kassymbayev
    ;
    ;
    Nurgul Mamytova
    Elaeagnus rhamnoides berries contain significant amounts of bioactive vitamins, lipids, carotenoids, and phenolic compounds. They are widely used as an ingredient in functional products, cosmetics, and pharmaceutical formulations to prevent and treat cardiovascular, stomach, skin, and liver diseases. Natural sea buckthorn populations are widespread in Kazakhstan. Data on phytochemical and diagnostic indicators are absent for E. rhamnoides growing in Kazakhstan. In this work, seaberry from Kazakhstan was surveyed for diagnostic indicators, lipophilic and hydrophilic compounds. Analyses were conducted for main diagnostic indicators of leaves and fruits by standard microtechniques; fatty acid profiles by gas-chromatography; β-carotene by HPLCPDA; vitamin C and B by capillary electrophoresis, and pectin substances by titration. The main diagnostic indicators of leaves were stomatal anomocytic complex; corymbose and stellate hairs; conductive bundle - closed collateral; fruits - secretory passages and conducting bundles of a spiral type in the pulp parenchyma, and a large amount of fatty oil and aleuron grains in the embryo. In the oil from berry pulp/peel, the dominating fatty acids were palmitoleic and palmitic (28.53 and 30.03 %, respectively). Sea buckthorn seed oil, with its high a-linolenic levels and a near 1:1 ratio of ω-6:ω-3 fatty acids, represented a very balanced source of polyunsaturated fatty acids for human health and nutrition. β-Carotene content was 7.75 mg per kg, pectin substances – 3.27 %. In addition, the berries were rich in vitamins B complex (0.0035-0.014 mg/100g) and vitamin C (0.21 mg/100g). This work constitutes the first approach on knowledge about the phytochemical profile of Elaeagnus rhamnoides fruits from Kazakhstan and provides arguments multiple using of E. rhamnoides, both for fresh consumption and for industrial preparations in the form of jams and related products (functional multivitamin food) as well as byproducts (seeds) as raw materials for the production of oils suitable to be marketed by the pharmaceutical, cosmetic and food industries.
    Цитирования (OpenAlex) 2Цитирования (OpenCitations) 1
  • Некоторые метрики заблокированы вашими 
    Тип записи:Публикация,
    Adaptation Features of Gentiana tianschanica Rupr. Populations to Environmental Factors in Kazakhstan
    (2024-01-01)
    Бекзат Тыныбеков
    ;
    ;
    Askhat Kuatbayev
    ;
    Gulmira Satybaldiyeva
    ;
    Elmira Boribay
    The study investigates the current state, floristic composition, and ecological characteristics of Gentiana tianschanica populations in the Ile-Alatau region, part of the Ile-Alatau National Park, Kazakhstan.Gentiana L., an ancient boreal genus, includes 31 species in Kazakhstan, such as the endemic Gentiana dschungarica.Known for medicinal uses, especially for gastrointestinal and urogenital disorders, interest in gentians has risen for ornamental and pharmacological applications.Nine natural populations of G. tianschanica were studied in diverse ecological and phytocoenotic conditions of the Ile-Alatau mountains.Soil analyses revealed significant differences in the physicochemical properties of the species' habitats.In the Kimasar Gorge, mountain-meadow chestnut soils with a light loamy texture were observed, while the Big Almaty Gorge featured dark chestnut soils rich in humus (7.36-18.78%)and nutrients such as nitrogen (120.4-140.0mg/kg), phosphorus (58-98 mg/kg), and potassium (470-1000 mg/kg).These findings emphasize the species 'adaptation to varying altitudinal and climatic zones.Phytochemical analysis showed G. tianschanica is rich in bioactive compounds, including phenolics, bitter glycosides, flavonoids, and alkaloids.Total phenol content reached 1567.17-9008.20mg of gallic acid/100 g, with the highest levels in leaves.Flavonoids (up to 1358.25 mg catechin/100 g) and vitamin C (up to 244.7 mg/100 g) were significant.Syringic acid (1685.8mg/100 g), quercetin (317.4 mg/100 g), and chlorogenic acid (237.5 mg/100 g) highlighted antioxidant and antiinflammatory potential.The antioxidant activity, particularly in leaves, reached 530.30 mg Trolox/100 g.Anthropogenic threats, including overgrazing and habitat disturbance, have led to declining populations, necessitating conservation strategies like habitat monitoring, protective regimes, and sustainable medicinal plant use.This study underscores the ecological and phytochemical significance of G. tianschanica, which is vital for biodiversity conservation and pharmaceutical development.
    Цитирования (OpenAlex) 2Цитирования (OpenCitations) 3
  • Некоторые метрики заблокированы вашими 
    Тип записи:Публикация,
    The Volatile Compounds Composition of Different Parts of Wild Kazakhstan Sedum ewersii Ledeb.
    (Multidisciplinary Digital Publishing Institute, 2024-07-05)
    Tatyana Kobylina
    ;
    Andriy Novikov
    ;
    Gulbanu Aueskhanovna Sadyrova
    ;
    ;
    The chemical composition of Sedum ewersii Ledeb., a plant indigenous to Kazakhstan and traditionally utilized in folk medicine, was comprehensively investigated, with a focus on its various plant parts. Fresh samples collected in May 2023 from the Almaty region underwent hydrodistillation to extract volatile components, followed by analysis using gas chromatography coupled with mass spectrometric detection, which identified a total of 71 compounds across different plant parts, including the root (underground part), root (aerial part), leaf, stem, and flowering aerial part. The predominant biologically active compound identified across all plant parts was Ethyl α-D-glucopyranoside. Monoterpenes, recognized as primary secondary metabolites, were notably abundant in each plant part, with varying compositions: the root (underground part) contained 28.58% aliphatic monoterpenes, 54.41% oxygenated monoterpenoids, 1.42% diterpenoids, and 15.59% other compounds; the root (aerial part) exhibited 1.34% aliphatic monoterpenes, 31.28% oxygenated monoterpenoids, 6.16% diterpenoids, and 61.22% other compounds; the stem and leaves showed 3.06% aliphatic monoterpenes, 21.49% oxygenated monoterpenoids, 17.99% diterpenoids, and 57.46% other compounds; and the flowering aerial part displayed 8.20% aliphatic monoterpenes, 53.18% oxygenated monoterpenoids, 23.75% diterpenoids, and 14.87% other compounds. Diterpenes, particularly Phytol, were prominently present in the leaf, stem, and flowering aerial parts. Additionally, a diverse array of organic acids, ketones, and phenolic compounds were identified across the plant parts, each potentially offering distinct pharmacological benefits. The presence of exclusive compounds in specific plant parts, such as Dihydroxyacetone in the root (aerial part), underscored the pharmacological diversity of S. ewersii. This study provides valuable insights into the chemical diversity and pharmacological potential of S. ewersii, suggesting promising applications in pharmaceutical and medicinal fields. Further research aimed at elucidating the individual and synergistic pharmacological effects of these compounds is crucial to fully harness the therapeutic benefits of this plant.
    Цитирования (OpenAlex) 6Цитирования (OpenCitations) 7
  • Некоторые метрики заблокированы вашими 
    Тип записи:Публикация,
    Phytochemical composition and antioxidant, antimicrobial, and cytotoxic activities of different solvent extracts of Ajania fastigiata (C. Winkl.) Poljakov
    (Instituto Internacional de Ecologia (Brazil), 2025-01-01)
    Assem Mamurova
    ;
    G. Kairanova
    ;
    G.A. Amеrtayeva
    ;
    Aigul Yedilova
    ;
    Asylkhan A. Rakhymzhan
    This study investigates the phytochemical composition and biological activities of six solvent extracts-hexane, ethyl acetate, and hydroethanolic fractions-from the roots and aerial parts of Ajania fastigiata (C. Winkl.) Poljakov (Asteraceae), collected in the mountain regions of southeastern Kazakhstan. Phytochemical analysis revealed that the aerial ethyl acetate extract contained the highest levels of bioactive metabolites, including phenolic compounds (34.22 ± 1.98 mg GAE/g), flavonoids (2.74%), organic acids (1.91%), and coumarins (0.54%). Antioxidant potential was evaluated using DPPH and ABTS radical-scavenging assays, with values of SC50 = 133.98 ± 12.91 µg/mL (DPPH) and 209.21 ± 3.70 mg Trolox/g (ABTS). The minimum inhibitory concentration (MIC), determined by the broth microdilution method, showed strong antimicrobial activity of the aerial ethyl acetate fraction, particularly against P.aeruginosa (MIC = 9 µg/mL) and E.faecalis (MIC = 39 µg/mL). Cytotoxicity was assessed by the MTT assay on NIH-3T3, K562, and Saos cell lines. The aerial ethyl acetate fraction exhibited selective cytotoxic effects, with IC50 values of 210 µg/mL for K562 and 360 µg/mL for Saos, while showing negligible activity toward normal fibroblasts (IC50 > 2500 µg/mL). These results confirm the pharmacological potential of A.fastigiata as a promising natural source of antioxidant, antimicrobial, and anticancer agents.
  • Некоторые метрики заблокированы вашими 
    Тип записи:Публикация,
    Phytochemical Profiling and Toxicological Evaluation of Atraphaxis virgata and Atraphaxis pyrifolia Extracts Using GC–MS and LC–MS
    (Multidisciplinary Digital Publishing Institute, 2026-05-23)
    Meruyert D. Dauletova
    ;
    Almagul K. Umbetova
    ;
    Aisulu Zh. Kabdraisova
    ;
    Ryzvangul S. Ymynova
    ;
    G. Sh. Burasheva
    Atraphaxis virgata and Atraphaxis pyrifolia are xerophytic species of the Polygonaceae family that remain insufficiently characterized from pharmacognostic, phytochemical, and toxicological perspectives. This study provides an integrated evaluation of both species through anatomical authentication, sequential extraction of CO2-extracted residual biomass, GC–MS and LC–MS metabolite profiling, and acute oral toxicity assessment. Anatomical analysis revealed shared xeromorphic traits, including cuticular protection, dorsiventral mesophyll organization, structured vascular bundles, and calcium oxalate druses. It also identified species-specific differences in leaf thickness, mesophyll arrangement, vascular architecture, and druse morphology. GC–MS analysis showed distinct chemical profiles: A. virgata displayed a concentrated profile dominated by acetophenone- and benzofuran-related constituents, whereas A. pyrifolia showed a broader spectrum of carbohydrate-derived, phenolic-related, and oxygenated constituents. LC–MS analysis supported the tentative annotation of diverse polyphenolic classes, including flavonoids, phenolic acids, coumarins, and phenylpropanoid derivatives. Acute oral toxicity testing showed no mortality at doses up to 2000 mg/kg, supporting a low acute oral toxicity classification under the tested conditions. However, histological examination revealed mild to moderate dose-dependent alterations in liver and kidney tissues at higher doses. The novelty of this work lies in linking diagnostic anatomical traits, species-specific metabolite patterns, residual biomass valorization, and preliminary safety evidence within a single comparative framework. These findings provide a basis for pharmacognostic authentication, phytochemical standardization, and future bioactivity-guided evaluation of Atraphaxis species.