Жарияланымдар / Публикации
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- Некоторые метрики заблокированы вашиминастройками согласия
Тип записи:Публикация, STUDY OF THE AMINO ACID AND ELEMENTAL COMPOSITION OF THE ABOVEGROUND PART OF XANTHIUM STRUMARIUM PLANTS(2020-01-01); ; ; ; The article contains materials on the study of the content of amino acids, macro-and microelements in the leaves and stems of Xanthium strumarium plants. The content of amino acids is determined by liquid chromatographic method. As a result, 10 amino acids (2 essential): arginine, threonine, alanine, proline, cysteine, licin, phenylalanine, lysine, oxyproline, serine, and the presence of 10 elements in them was noted. It was determined that the dry extract from the aboveground part of Xanthium strumarium is a source of amino acids, macro-and microelements. References [1] Sharifi-rad J., Hoseini-Alfatemi S. M., Sharifi-rad M. A., Miri, Sharifi-rad M. phytochemical screening and antibacterial activity of the plant prosopis farcta extracts of various parts against methicillin-resistant Staphylococcus aureus (MRSA) // Biotecnol Minerva. 2014, 26, 287-293. [2] Qin L., Hana T. G. Lib, V. Zhang, Zhenga H. A. New thiazinedione from Zantium strumarium // Fitoterapia. 2006, 77, 245-246. [3] Sucheta Gaikwad, Rasika Torane, Kavita Mundhe (2016). Preliminary screening and comparative evaluation of the antioxidant potential of the drug-important plant Xanthium strumarium L. // Journal of pharmacognosy and Phytochemistry. 5 (2): 141-144. [4] Han T., Li H. L., Zhang Q. Y., Zheng H. C., Qin L. P. new thiazindiones and other comonents from Xanthium strumarium L. // Chemistry. Natural. Company. 42 (5); 2006, 567-570. [5] Bushueva G.R. Durnishnik ordinary (xanthium strumarium) ‒ a promising source of biologically active compounds(review) // The issue of the journal of quality assurance in pharmaceutical formulations. № 2(16). 2017. [6] Kim I.T., Park Y.M., Won I.N. et al. Methanol extract of Xanthium strumarium L. has antiinflammatory and antinociceptive activity // Biol. Apothecary. Bull. 2005; 28: 94-100. [7] Pupykina K.A., Mironova L.N., Denisova S.G., fayzullina R.R. Study of amino acid and elemental composition of underground organs of some representatives of the genus Dalia Kev // Vestn. VSU. Ser. Geography. [8] State Pharmacopoeia of the Russian Federation. XIII ed. Moscow, 2015. Vol. 2. [9] Azimbayeva G.E., Abdikerim M.S. Chemical research and isolation of polysaccharides from the aboveground part of the plant Arctium Lappa // Chemical journal of Kazakhstan. Almaty, 2020, 1(69). [10] Grinkevich N.I. Chemical analysis of medicinal plants. Moscow: Higher school, 1983. 176 p. [11] Scherer R., Wagner R., Meireles A.M.A. Godoy H.T. Duarte, S.M.T., Filho, Zh.T. biological activity and chemical composition of hydro-distilled and supercritical extracts of common durnishnik leaves // Journal Essent. Oil Research 2010, 22, 424-429.Цитирования (OpenAlex) 1 - Некоторые метрики заблокированы вашиминастройками согласия
Тип записи:Публикация, The Iodine–Dextrin–Lithium Complex: Morphology, Antibacterial Activity, and Cytotoxicity(Multidisciplinary Digital Publishing Institute, 2025-12-18) ;Daniil Shepilov; ;Ardak B. Jumagaziyeva ;Tamara BukeyevaDana A. AskarovaA new iodine-dextrin-lithium complex (IDLC) was synthesized and structurally characterized as a hybrid supramolecular system combining antiseptic, stabilizing, and biocompatible components. The compound integrates iodine as the primary antimicrobial agent, lithium as a coordination and stabilization element, and dextrin as a biodegradable polysaccharide matrix enabling sustained release. Physicochemical analyses confirmed the formation of a uniform, thermally stable complex. Biological evaluation revealed strong bactericidal activity, with minimum bactericidal concentrations (MBC) ranging from 1.95 to 15.63 µg ml-1 against both Gram-positive and Gram-negative pathogens, including multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii. The complex also demonstrated inhibitory effects in virus-infected MDCK cell cultures. Cytotoxicity studies showed CC50 = 0.23-0.48 mg ml-1 on human MNCs and more than 10 mg ml-1 on MDCK cells, confirming low toxicity. The results of the study on the cytotoxicity of IDLC suggest a cytotoxic effect on tumor cell lines such as HepG2, HeLa, AGS, K562, and H9, as well as normal cell lines MeT-5A. Therefore, it can be estimated that IDLC has the potential to be a new drug with antitumor activity against these cell lines. The research confirms that iodine can be effectively stabilized within a dextrin-lithium framework to yield a biologically active, thermally resistant complex, suitable for pharmaceutical use.Цитирования (OpenAlex) 3
