Жарияланымдар / Публикации

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Дата начала: 2020Тема: search.filters.subject.antibacterial activity

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    Тип записи:Публикация,
    STUDY OF THE AMINO ACID AND ELEMENTAL COMPOSITION OF THE ABOVEGROUND PART OF XANTHIUM STRUMARIUM PLANTS
    (2020-01-01)
    G. E. Azimbayeva
    ;
    M. S. Abdikerim
    ;
    B. M. Izteleu
    ;
    Kenzhegul Smailova
    ;
    A. K. Kamysbayeva
    The article contains materials on the study of the content of amino acids, macro-and microelements in the leaves and stems of Xanthium strumarium plants. The content of amino acids is determined by liquid chromatographic method. As a result, 10 amino acids (2 essential): arginine, threonine, alanine, proline, cysteine, licin, phenylalanine, lysine, oxyproline, serine, and the presence of 10 elements in them was noted. It was determined that the dry extract from the aboveground part of Xanthium strumarium is a source of amino acids, macro-and microelements. References [1] Sharifi-rad J., Hoseini-Alfatemi S. M., Sharifi-rad M. A., Miri, Sharifi-rad M. phytochemical screening and antibacterial activity of the plant prosopis farcta extracts of various parts against methicillin-resistant Staphylococcus aureus (MRSA) // Biotecnol Minerva. 2014, 26, 287-293. [2] Qin L., Hana T. G. Lib, V. Zhang, Zhenga H. A. New thiazinedione from Zantium strumarium // Fitoterapia. 2006, 77, 245-246. [3] Sucheta Gaikwad, Rasika Torane, Kavita Mundhe (2016). Preliminary screening and comparative evaluation of the antioxidant potential of the drug-important plant Xanthium strumarium L. // Journal of pharmacognosy and Phytochemistry. 5 (2): 141-144. [4] Han T., Li H. L., Zhang Q. Y., Zheng H. C., Qin L. P. new thiazindiones and other comonents from Xanthium strumarium L. // Chemistry. Natural. Company. 42 (5); 2006, 567-570. [5] Bushueva G.R. Durnishnik ordinary (xanthium strumarium) ‒ a promising source of biologically active compounds(review) // The issue of the journal of quality assurance in pharmaceutical formulations. № 2(16). 2017. [6] Kim I.T., Park Y.M., Won I.N. et al. Methanol extract of Xanthium strumarium L. has antiinflammatory and antinociceptive activity // Biol. Apothecary. Bull. 2005; 28: 94-100. [7] Pupykina K.A., Mironova L.N., Denisova S.G., fayzullina R.R. Study of amino acid and elemental composition of underground organs of some representatives of the genus Dalia Kev // Vestn. VSU. Ser. Geography. [8] State Pharmacopoeia of the Russian Federation. XIII ed. Moscow, 2015. Vol. 2. [9] Azimbayeva G.E., Abdikerim M.S. Chemical research and isolation of polysaccharides from the aboveground part of the plant Arctium Lappa // Chemical journal of Kazakhstan. Almaty, 2020, 1(69). [10] Grinkevich N.I. Chemical analysis of medicinal plants. Moscow: Higher school, 1983. 176 p. [11] Scherer R., Wagner R., Meireles A.M.A. Godoy H.T. Duarte, S.M.T., Filho, Zh.T. biological activity and chemical composition of hydro-distilled and supercritical extracts of common durnishnik leaves // Journal Essent. Oil Research 2010, 22, 424-429.
    Цитирования (OpenAlex) 1
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    Тип записи:Публикация,
    The Iodine–Dextrin–Lithium Complex: Morphology, Antibacterial Activity, and Cytotoxicity
    (Multidisciplinary Digital Publishing Institute, 2025-12-18)
    Daniil Shepilov
    ;
    Seitzhan Turganbay
    ;
    Ardak B. Jumagaziyeva
    ;
    Tamara Bukeyeva
    ;
    Dana A. Askarova
    A new iodine-dextrin-lithium complex (IDLC) was synthesized and structurally characterized as a hybrid supramolecular system combining antiseptic, stabilizing, and biocompatible components. The compound integrates iodine as the primary antimicrobial agent, lithium as a coordination and stabilization element, and dextrin as a biodegradable polysaccharide matrix enabling sustained release. Physicochemical analyses confirmed the formation of a uniform, thermally stable complex. Biological evaluation revealed strong bactericidal activity, with minimum bactericidal concentrations (MBC) ranging from 1.95 to 15.63 µg ml-1 against both Gram-positive and Gram-negative pathogens, including multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii. The complex also demonstrated inhibitory effects in virus-infected MDCK cell cultures. Cytotoxicity studies showed CC50 = 0.23-0.48 mg ml-1 on human MNCs and more than 10 mg ml-1 on MDCK cells, confirming low toxicity. The results of the study on the cytotoxicity of IDLC suggest a cytotoxic effect on tumor cell lines such as HepG2, HeLa, AGS, K562, and H9, as well as normal cell lines MeT-5A. Therefore, it can be estimated that IDLC has the potential to be a new drug with antitumor activity against these cell lines. The research confirms that iodine can be effectively stabilized within a dextrin-lithium framework to yield a biologically active, thermally resistant complex, suitable for pharmaceutical use.
    Цитирования (OpenAlex) 3
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    Тип записи:Публикация,
    Culturable rhizosphere bacteria associated with Alcea nudiflora (Lindl.) Boiss. in the Zailiyskiy Alatau (Kazakhstan): isolation, characterization and functional potential
    (Instituto Internacional de Ecologia (Brazil), 2026-01-01)
    Akerke Abil
    ;
    Kadir Akan
    ;
    Zhansaya Abdukadirova
    ;
    Damira Yussayeva
    ;
    G. D. Ultanbekova
    Abstract The rhizosphere of medicinal plants represents a reservoir of culturable bacteria with potential value for plant protection and biotechnology. In this study, we characterized the culturable rhizosphere bacterial community associated with Alcea nudiflora (Lindl.) Boiss. collected from three sites in the Zailiyskiy Alatau. Rhizosphere microorganisms were isolated using tenfold serial dilutions followed by plating on meat-peptone agar and oatmeal agar, purified by streaking, and phenotypically characterized by colony morphology, Gram staining, and motility assays. Nineteen morphologically distinct isolates were recovered and grouped into four morphotypes: Streptomyces-like actinomycetes, Bacillus-like spore-forming rods, coryneform bacteria, and coccoid forms. All isolates showed a Gram-positive reaction. Antagonistic activity was screened using agar well diffusion, disk diffusion, and agar block assays against test microorganisms (Escherichia coli, Staphylococcus aureus, Candida albicans, C. utilis, Aspergillus niger, Fusarium oxysporum and Penicillium chrysogenum). Several isolates exhibited broad or target-specific antagonism, including strains 5/1 (balanced antibacterial and antifungal activity), 4/7 and 7/1 (anti-staphylococcal activity), 9/3 and 8/2 (antifungal activity, including against Candida spp.), and 1/2 (specific activity against A. niger). Overall, these results provide a baseline characterization of the culturable rhizosphere bacteria associated with Alcea nudiflora (Lindl.) Boiss. in this region and identify candidate isolates for molecular identification and plant-focused validation.