Результаты поиска

Показано: 1 - 2 из 2

Некоторые метрики заблокированы вашими
настройками согласия
Phytochemical composition and antioxidant, antimicrobial, and cytotoxic activities of different solvent extracts of Ajania fastigiata (C. Winkl.) Poljakov
(Instituto Internacional de Ecologia (Brazil), 2025-01-01)
Assem Mamurova
;
G. Kairanova
;
G.A. Amеrtayeva
;
Aigul Yedilova
;
Asylkhan A. Rakhymzhan
This study investigates the phytochemical composition and biological activities of six solvent extracts-hexane, ethyl acetate, and hydroethanolic fractions-from the roots and aerial parts of Ajania fastigiata (C. Winkl.) Poljakov (Asteraceae), collected in the mountain regions of southeastern Kazakhstan. Phytochemical analysis revealed that the aerial ethyl acetate extract contained the highest levels of bioactive metabolites, including phenolic compounds (34.22 ± 1.98 mg GAE/g), flavonoids (2.74%), organic acids (1.91%), and coumarins (0.54%). Antioxidant potential was evaluated using DPPH and ABTS radical-scavenging assays, with values of SC50 = 133.98 ± 12.91 µg/mL (DPPH) and 209.21 ± 3.70 mg Trolox/g (ABTS). The minimum inhibitory concentration (MIC), determined by the broth microdilution method, showed strong antimicrobial activity of the aerial ethyl acetate fraction, particularly against P.aeruginosa (MIC = 9 µg/mL) and E.faecalis (MIC = 39 µg/mL). Cytotoxicity was assessed by the MTT assay on NIH-3T3, K562, and Saos cell lines. The aerial ethyl acetate fraction exhibited selective cytotoxic effects, with IC50 values of 210 µg/mL for K562 and 360 µg/mL for Saos, while showing negligible activity toward normal fibroblasts (IC50 > 2500 µg/mL). These results confirm the pharmacological potential of A.fastigiata as a promising natural source of antioxidant, antimicrobial, and anticancer agents.
Некоторые метрики заблокированы вашими
настройками согласия
Comparative Anatomical analysis of Zygophyllum fabago L. populations from the Ili-Balkhash region, Kazakhstan
(2026-03-16)
Assem Mamurova
;
G. Kairanova
;
Zhansaya Abdualiyeva
;
Aidana Toregeldiyeva
;
Молдир Жумагул
Zygophyllum fabago L. is recognized as a valuable medicinal species traditionally applied in the treatment of rheumatism, inflammatory and dermatological disorders, urinary tract problems, and intestinal parasitic infections. In the present work, a comparative anatomical study was performed on specimens collected from three natural populations located near the villages of Topar, Bakanas, and Miyaly within the Ili-Balkhash region of Kazakhstan. The objective was to characterize the variability of vegetative-organ anatomy in relation to soil differences such as salinity, compaction, and nutrient supply. Samples were preserved in 70 % ethanol, embedded in paraffin, and sectioned at 40 μm with a rotary microtome (MEDITE M530). Microscopic observations were carried out using a Levenhuk D740T instrument, and dimensional data were obtained with the LevenhukLite software package. Among the studied populations, root periderm thickness ranged from 119.35 μm (Pop. 1) to 168.54 μm (Pop. 3). The thickest xylem was observed in Pop. 3 (860.65 μm), suggesting improved hydraulic conductance, while the most developed mesophyll layers occurred in the same group, where palisade and spongy tissues reached 728.51 μm and 843.68 μm, respectively. Such structural variation demonstrates the pronounced adaptive flexibility of Z.fabago under contrasting edaphic conditions. This investigation provides the first comprehensive anatomical characterization of the species from southern Kazakhstan, emphasizing the diagnostic importance of tissue traits for assessing ecological resilience and the potential of Z.fabago in restoring arid and saline landscapes.
Цитирования (OpenAlex) 1

Жарияланымдар / Публикации

Просмотр

Фильтры

Настройки

Сортировать по

результатов на странице

Результаты поиска

QyzPU CRIS

Университет

Данные